Symbol
Name
ID

Rc3h1
RING CCCH (C3H) domains 1
MGI:2685397

Phenotype annotations related to hematopoietic system

Darker colors indicate more annotations

Mouse Phenotypes

increased T cell proliferation

abnormal thymus development

enlarged spleen

increased spleen weight

spleen hyperplasia

abnormal B cell differentiation

decreased immature B cell number

abnormal T cell differentiation

anemia

decreased bone marrow cell number

increased eosinophil cell number

thrombocytopenia

decreased B cell number

increased B cell number

increased T follicular helper cell number

increased CD4-positive, alpha-beta T cell number

increased CD8-positive, alpha-beta T cell number

abnormal intraepithelial T cell number

increased regulatory T cell number

increased activated T cell number

increased macrophage cell number

abnormal effector T cell morphology

abnormal spleen B cell follicle morphology

increased splenocyte number

abnormal germinal center B cell physiology

decreased IgA level

decreased IgG1 level

increased IgG2b level

decreased IgG3 level

increased IgG level

abnormal T follicular helper cell physiology

Availability

Mouse Genotype

Rc3h1^san/Rc3h1^san

Rc3h1^tm1.2Mass/Rc3h1^tm1.2Mass

Rc3h1^san/Rc3h1⁺

Rc3h1^tm1.2Cgv/Rc3h1^san

Rc3h1^tm1.1Mass/Rc3h1^tm1.1Mass
Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺ (conditional)

Rc3h1^tm1.1Mass/Rc3h1^tm1.1Mass
Tg(Cd4-cre)1Cwi/0 (conditional)

Rc3h1^tm1.1Mass/Rc3h1^tm1.1Mass
Cd19^tm1(cre)Cgn/Cd19⁺ (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/23/2024 MGI 6.23